P-糖蛋白在K-562和DAUDI细胞中的过表达与对自然杀伤细胞（NK）和淋巴因子激活的杀伤细胞（LAK）的高敏感性相关。
The over-expression of P-glycoprotein in K-562 and DAUDI cells, is associated with a high susceptibility to NK and LAK cells.
作者信息
Dupuis M L, Ramoni C, Yassen A, Samoggia P, Tombesi M, Caserta M, Cianfriglia M
机构信息
Immunology Laboratory, Higher Institute of Health, Roma, Italy.
出版信息
J Biol Regul Homeost Agents. 1991 Oct-Dec;5(4):137-41.
We evaluated the susceptibility to natural killer (NK) or lymphokine activated killer (LAK) cell-mediated cytolysis of two pairs of drug sensitive/resistant tumor cell lines which were extensively characterized at phenotypic and genotypic level. In the DAUDI cell system, the acquired capability of tumor cell variants to grow in the presence of a relatively high concentration of vinblastine (VBL) is associated with a marked increase to NK and LAK susceptibility. In contrast in the K-562 cell system, no correlation between drug-resistance, P-glycoprotein expression and susceptibility to NK or LAK activity seems to occur.
我们评估了两对在表型和基因型水平上得到广泛表征的药物敏感/耐药肿瘤细胞系对自然杀伤（NK）细胞或淋巴因子激活的杀伤（LAK）细胞介导的细胞溶解作用的敏感性。在DAUDI细胞系统中，肿瘤细胞变体在相对高浓度长春碱（VBL）存在下生长的获得性能力与对NK和LAK敏感性的显著增加相关。相比之下，在K-562细胞系统中，耐药性、P-糖蛋白表达与对NK或LAK活性的敏感性之间似乎没有相关性。
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