12-氮杂埃坡霉素（氮杂埃坡霉素）的设计与合成——具有强大抗癌活性的“非天然”天然产物 - Suppr

Design and synthesis of 12-aza-epothilones (azathilones)--"non-natural" natural products with potent anticancer activity.

作者信息

Feyen Fabian, Gertsch Jürg, Wartmann Markus, Altmann Karl-Heinz

机构信息

ETH Zürich, Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, ETH Hönggerberg, HCI H 405, 8093 Zürich, Switzerland.

出版信息

Angew Chem Int Ed Engl. 2006 Sep 4;45(35):5880-5. doi: 10.1002/anie.200601359.

DOI:10.1002/anie.200601359

PMID:16871640

Abstract

摘要

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Design and synthesis of 12-aza-epothilones (azathilones)--"non-natural" natural products with potent anticancer activity.

作者信息

Feyen Fabian, Gertsch Jürg, Wartmann Markus, Altmann Karl-Heinz

机构信息

ETH Zürich, Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, ETH Hönggerberg, HCI H 405, 8093 Zürich, Switzerland.