环缩酚酸肽合孢素及其类似物的合成与抗肿瘤活性

Synthesis and antitumor activity of cyclodepsipeptide zygosporamide and its analogues.

作者信息

Wang You, Zhang Feiran, Zhang Yihua, Liu Jun O, Ma Dawei

机构信息

Center of Drug Discovery, China Pharmaceutical University, Nanjing 210009, China.

出版信息

Bioorg Med Chem Lett. 2008 Aug 1;18(15):4385-7. doi: 10.1016/j.bmcl.2008.06.066. Epub 2008 Jun 21.

DOI:10.1016/j.bmcl.2008.06.066

PMID:18606540

Abstract

The synthesis and structure-activity relationships of zygosporamide, a known potent and selective cytotoxic natural product against SF-268 and RXF 393 cell lines, are described. The potencies of the synthetic zygosporamide are similar to those reported for the natural product toward all cancer cell lines examined with the exception of SF-268, the underlying cause of which remains to be elucidated.

摘要

本文描述了已知对SF-268和RXF 393细胞系具有强效和选择性细胞毒性的天然产物合孢酰胺的合成及其构效关系。除SF-268细胞系外，合成合孢酰胺对所有检测的癌细胞系的活性与天然产物报道的活性相似，其潜在原因仍有待阐明。