Miao C Y, Zhang F L, Zhu Q Y, Zhang K H, Su D F
Department of Pharmacology, Second Military Medical University, Shanghai, China.
Zhongguo Yao Li Xue Bao. 1991 Jul;12(4):352-4.
Tetrandrine (Tet) 5 mg.kg-1 i.v. inhibited the pressor action of norepinephrine (NE) release induced by electric stimulation (10 V, 0.5-16 Hz) of spinal cord T11-L2. However, Tet 5 mg.kg-1 ia did not obviously attenuate the hypertensive responses to NE 0.51-16.91 micrograms.kg-1 i.v., indicating that Tet did not affect the alpha 1-adrenoceptors-mediated vasoconstriction. Tet 5 mg.kg-1 ia decreased the pressor responses to NE 0.05 and 0.17 micrograms.kg-1 i.v. and markedly reduced the dose-dependent hypertensive responses to B-HT920 i.v., a selective alpha 2-adrenoceptor agonist, proving that Tet reduced alpha 2-adrenoceptors-mediated vasoconstriction.
汉防己甲素（Tet）5毫克·千克-1静脉注射可抑制由脊髓T11-L2电刺激（10伏，0.5 - 16赫兹）诱导的去甲肾上腺素（NE）释放所引起的升压作用。然而，Tet 5毫克·千克-1腹腔注射并未明显减弱对0.51 - 16.91微克·千克-1静脉注射NE的高血压反应，表明Tet不影响α1 - 肾上腺素能受体介导的血管收缩。Tet 5毫克·千克-1腹腔注射降低了对0.05和0.17微克·千克-1静脉注射NE的升压反应，并显著降低了对选择性α2 - 肾上腺素能受体激动剂B-HT920静脉注射的剂量依赖性高血压反应，证明Tet降低了α2 - 肾上腺素能受体介导的血管收缩。
