Hines Ronald N, McCarver D Gail
Department of Pediatrics, Section of Clinical Pharmacology, Pharmacogenetics and Teratology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.
Pediatr Clin North Am. 2006 Aug;53(4):591-619. doi: 10.1016/j.pcl.2006.05.008.
With the completion of the human genome project, many investigators are striving to translate the resulting wealth of new information into new and improved clinical practices. Pharmacogenomics represents one of the most promising of these applications for adult- and pediatric-based therapies. This article provides a historical perspective, but most importantly, uses this background to illustrate important principles of the field. The application of pharmacogenomics to asthma therapy is presented as an example of the current status of pharmacogenomics as it is being applied to an important pediatric health problem. Finally, a discussion of future promises and challenges to the application of pharmacogenomics is presented, including economic and ethical issues.
随着人类基因组计划的完成，许多研究人员正努力将由此产生的大量新信息转化为新的、更完善的临床实践。药物基因组学是这些应用中最具前景的领域之一，适用于成人和儿童治疗。本文提供了一个历史视角，但最重要的是，利用这一背景来说明该领域的重要原则。药物基因组学在哮喘治疗中的应用作为一个例子，展示了药物基因组学在解决一个重要儿科健康问题方面的现状。最后，讨论了药物基因组学应用的未来前景和挑战，包括经济和伦理问题。
