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精神药理学:脑神经化学的临床意义

Psychopharmacology: clinical implications of brain neurochemistry.

作者信息

Scheffer Russell E

机构信息

Child and Adolescent Psychiatry and Behavioral Medicine, Medical College of Wisconsin and Children's Hospital of Wisconsin, 9000 West Wisconsin Avenue, MS 750, Milwaukee, WI 53201, USA.

出版信息

Pediatr Clin North Am. 2006 Aug;53(4):767-75. doi: 10.1016/j.pcl.2006.05.012.

Abstract

There is an increasing prescription of psychotropic medications to youth. This use is accompanied by a developing, but lagging, evidence base for this use. These agents predominantly interact with regulatory neurotransmitters, which have known functions in the developing embryo. This article reviews major diagnostic categories in regards to the biological basis of the mainstays of pharmacology for each condition. Adverse events also are discussed in regards to these common psychopharmacological agents. There is growing evidence that the consequences of not treating serious psychiatric illnesses outweigh known risks of the medications. Prescription practices should endeavor to limit adverse consequences whenever possible.

摘要

青少年使用精神药物的处方量在不断增加。这种使用伴随着针对该用途的证据基础不断发展但仍滞后的情况。这些药物主要与调节性神经递质相互作用,而调节性神经递质在发育中的胚胎中具有已知功能。本文回顾了每种病症药理学主要药物的生物学基础方面的主要诊断类别。还讨论了这些常见精神药物的不良事件。越来越多的证据表明,不治疗严重精神疾病的后果超过了药物已知的风险。处方实践应尽可能努力限制不良后果。

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