通过巢式聚合酶链反应检测HIV感染患者脑脊液中的水痘带状疱疹病毒DNA：一项前瞻性评估。

Detection of varicella-zoster virus DNA by nested PCR in CSF from HIV-infected patients: A prospective evaluation.

作者信息

Brink N S, Fox J D, Waite J C, Sharvell Y, Miller R F

机构信息

Division of Virology, University College London Hospitals NHS Trust, Windeyer Building, 46 Cleveland Street, London, W1P 6DB.

出版信息

J NeuroAIDS. 1998;2(1):99-105. doi: 10.1300/J128v02n01_07.

DOI:10.1300/J128v02n01_07

PMID:16873188

Abstract

The aim of this prospective study was to determine the frequency and clinical significance of detection of varicella-zoster virus (VZV) DNA in cerebrospinal fluid (CSF) from 120 HIV-infected individuals. Six of 8 CSF samples from patients with recent (up to 8 months previously) or concurrent cutaneous zoster contained detectable VZV DNA using the polymerase chain reaction. No detectable CSF VZV DNA was present in two patients who had an encephalopathy complicating cutaneous zoster or in 112 other patients without a history of recent of concurrent zoster. In conclusion, VZV DNA may be detected in CSF of patients with neurological disease and concurrent or recent zoster. However, the absence of detectable VZV DNA in CSF does not preclude the possibility of VZV associated neurological complications.

摘要

这项前瞻性研究的目的是确定120名感染HIV个体的脑脊液（CSF）中水痘-带状疱疹病毒（VZV）DNA检测的频率及其临床意义。使用聚合酶链反应，8例近期（最长8个月前）或同时患有皮肤带状疱疹患者的脑脊液样本中有6例检测到可检测的VZV DNA。在2例患有并发皮肤带状疱疹脑病的患者或112例无近期或同时带状疱疹病史的其他患者中，未检测到脑脊液VZV DNA。总之，患有神经疾病且并发或近期患有带状疱疹的患者脑脊液中可能检测到VZV DNA。然而，脑脊液中未检测到可检测的VZV DNA并不排除VZV相关神经并发症的可能性。