Winston K R, Breeze R E
Department of Surgery (Neurosurgery), University of Colorado, Denver.
Neurol Res. 1991 Dec;13(4):237-47. doi: 10.1080/01616412.1991.11739999.
A mechanism for the hydraulic regulation of brain parenchymal volume is hypothesized. Ventricular fluid pressure is transmitted to parenchymal capillaries and affects the pressure difference across the capillary wall, thereby influencing the rate of movement of fluid from the capillary lumen to interstitial fluid. The tendency for brain parenchyma to expand results from the resistance encountered by interstitial fluid as it slowly passes through the complex interstices of extracellular space. The tendency for the brain parenchyma to become smaller results, not from compression of tissue by ventricular fluid, but from an inherent elasticity of brain tissue. The parenchymal volume is stable only when the opposing tendencies are balanced. The critical site of action for the hydraulic control of parenchymal volume is the capillary wall, and the fundamental relationship governing this can be expressed mathematically.
一种关于脑实质容积液压调节的机制被提出假设。脑室液压力传递至脑实质毛细血管，并影响跨毛细血管壁的压力差，从而影响液体从毛细血管腔向间质液的移动速率。脑实质扩张的趋势源于间质液缓慢通过细胞外间隙复杂孔隙时所遇到的阻力。脑实质变小的趋势并非源于脑室液对组织的挤压，而是源于脑组织固有的弹性。只有当相反的趋势达到平衡时，脑实质容积才会稳定。对脑实质容积进行液压控制的关键作用部位是毛细血管壁，并且支配这一过程的基本关系可用数学方式表示。
