依巴斯汀对小鼠、大鼠和豚鼠II-IV型过敏反应的抑制作用。
Inhibitory effect of epinastine on the type II-IV allergic reactions in mice, rats and guinea pigs.
作者信息
Kamei C, Izushi K, Adachi Y, Shimazawa M, Tasaka K
机构信息
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University, Japan.
出版信息
Arzneimittelforschung. 1991 Nov;41(11):1150-3.
The inhibitory effect of epinastine (WAL 801 CL, CAS 80012-43-7) on types II, III and IV allergic reactions was studied. Epinastine caused an inhibition of type II allergic reactions: 1. the swelling of rat foot pad induced by a subcutaneous injection of anti-rat rabbit antiserum, and 2. lethality induced by an intravenous injection of anti-SRBC (sheep red blood cells) rabbit serum into guinea pigs (Forssman systemic reaction). The drug also caused an inhibition of the early phase in active Arthus reaction in guinea pigs (type III reactions). However, no significant inhibition was detected in the delayed-hypersensitivity reaction (type IV allergic response) induced by sheep red blood cells or picryl chloride in mice.
研究了依巴斯汀（WAL 801 CL，化学物质登记号80012 - 43 - 7）对II型、III型和IV型过敏反应的抑制作用。依巴斯汀可抑制II型过敏反应：1. 皮下注射抗大鼠兔抗血清所致大鼠足垫肿胀；2. 豚鼠静脉注射抗绵羊红细胞（SRBC）兔血清所诱导的致死性（福斯曼全身反应）。该药物还可抑制豚鼠主动阿图斯反应的早期阶段（III型反应）。然而，在小鼠中由绵羊红细胞或苦味酸诱导的迟发型超敏反应（IV型过敏反应）未检测到明显抑制作用。
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