淋巴毒素-α基因中的功能性多态性与颈动脉壁厚度相关：糖尿病心脏研究。
A functional polymorphism in the lymphotoxin-alpha gene is associated with carotid artery wall thickness: the Diabetes Heart Study.
作者信息
Liu Yongmei, Herrington David, Burdon Kathryn P, Langefeld Carl D, Rich Stephen S, Bowden Donald W, Freedman Barry I, Wagenknecht Lynne E
机构信息
Departments of Public Health Sciences bInternal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
出版信息
Eur J Cardiovasc Prev Rehabil. 2006 Aug;13(4):655-7. doi: 10.1097/01.hjr.0000214610.83866.2e.
BACKGROUND
The lymphotoxin-alpha (LTA) gene has been implicated in the pathogenesis of atherosclerosis. We tested for an association between a functional polymorphism, LTA 252A/G, and common carotid artery intima-media thickness in 1088 siblings from 435 Diabetes Heart Study families.
METHODS
Intima-media thickness was measured by high-resolution B-mode carotid ultrasonography. A MassARRAY system (Sequenom Inc., San Diego, California, USA) was used for genotyping.
RESULTS
The LTA 252G allele was positively associated with increased intima-media thickness (the odds ratio for the G allele carriers being in the top tertile of the intima-media thickness distribution was 1.41, P=0.04).
CONCLUSIONS
The LTA 252A/G polymorphism is moderately associated with sub-clinical atherosclerosis.
背景
淋巴毒素-α（LTA）基因与动脉粥样硬化的发病机制有关。我们在来自435个糖尿病心脏研究家庭的1088名兄弟姐妹中，检测了功能性多态性LTA 252A/G与颈总动脉内膜中层厚度之间的关联。
方法
采用高分辨率B型颈动脉超声测量内膜中层厚度。使用MassARRAY系统（美国加利福尼亚州圣地亚哥的Sequenom公司）进行基因分型。
结果
LTA 252G等位基因与内膜中层厚度增加呈正相关（G等位基因携带者在内膜中层厚度分布处于最高三分位数的优势比为1.41，P = 0.04）。
结论
LTA 252A/G多态性与亚临床动脉粥样硬化中度相关。
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