Tarayre J P, Aliaga M, Barbara M, Malfetes N, Vieu S, Tisne-Versailles J
Centre de Recherche Pierre Fabre, Castres, France.
J Pharm Pharmacol. 1991 Dec;43(12):877-9. doi: 10.1111/j.2042-7158.1991.tb03201.x.
The action of theophylline was studied on the inflammatory reaction obtained in bronchoalveolar lavage fluid 24 h after an active anaphylactic shock had been induced by ovalbumin inhalation in conscious sensitized guinea-pigs. The compound was administered twice by intraperitoneal administration after the anaphylactic reaction at a dose of 50 mg kg-1. When the guinea-pigs were sensitized by intramuscular injection of 30 mg kg-1 ovalbumin or by ovalbumin aerosol, theophylline reduced the number of eosinophils and mononuclear cells in the fluid. When animals were sensitized by intramuscular injection of 30 mg kg-1 ovalbumin mixed with Freund's complete adjuvant, treatment with the xanthine derivative decreased only the number of eosinophils. In the three models theophylline did not modify significantly the number of neutrophils. Thus theophylline always reduced pulmonary eosinophilia irrespective of the mode of sensitization used to induce anaphylactic shock.
在清醒的致敏豚鼠中，通过吸入卵清蛋白诱导主动过敏休克24小时后，研究了茶碱对支气管肺泡灌洗液中炎症反应的作用。在过敏反应后，以50 mg/kg的剂量通过腹腔注射给予该化合物两次。当豚鼠通过肌肉注射30 mg/kg卵清蛋白或通过卵清蛋白气雾剂致敏时，茶碱减少了灌洗液中嗜酸性粒细胞和单核细胞的数量。当动物通过肌肉注射30 mg/kg卵清蛋白与弗氏完全佐剂混合致敏时，用黄嘌呤衍生物治疗仅减少了嗜酸性粒细胞的数量。在这三种模型中，茶碱并未显著改变中性粒细胞的数量。因此，无论用于诱导过敏休克的致敏方式如何，茶碱总能减轻肺部嗜酸性粒细胞增多。
