Ahveninen Jyrki, Jääskeläinen Iiro P, Osipova Daria, Huttunen Matti O, Ilmoniemi Risto J, Kaprio Jaakko, Lönnqvist Jouko, Manninen Marko, Pakarinen Satu, Therman Sebastian, Näätänen Risto, Cannon Tyrone D
Department of Radiology, Harvard Medical School-Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA.
Biol Psychiatry. 2006 Sep 15;60(6):612-20. doi: 10.1016/j.biopsych.2006.04.015. Epub 2006 Jul 28.
Information on the inheritance of neurophysiological abnormalities might help elucidate the molecular genetic basis of schizophrenia. We used magnetoencephalography (MEG) and electroencephalography (EEG) to investigate the inheritance of auditory-cortical deficiencies in twin pairs discordant for schizophrenia.
Auditory EEG/MEG responses to frequent standard and occasional deviant tones were measured in mono- and dizygotic (MZ and DZ) twin pairs discordant for schizophrenia and demographically matched healthy twin pairs, recruited from a total population cohort. The MEG/EEG results were regressed against the genetic resemblance to patients with schizophrenia across the patients' unaffected MZ/DZ co-twins and control subjects (with genetic correlations of 1, .5, and 0 to schizophrenia patients, respectively).
The EEG responses P50, N100, and mismatch negativity (MMN), as well as the MEG response P50m, were reduced in the schizophrenic patients. P50 and N100 were significantly decreased also in their unaffected co-twins, as compared with the control subjects. Importantly, the P50 and N100 decrease correlated with the unaffected subjects' genetic resemblance to schizophrenia patients.
Our results suggest inherited abnormalities in cortical auditory processing in schizophrenia, reflected by the decreased P50/P50m and N100 amplitudes, whereas the MMN abnormalities might reflect predominantly state-dependent neurodegeneration.
关于神经生理异常遗传的信息可能有助于阐明精神分裂症的分子遗传基础。我们使用脑磁图（MEG）和脑电图（EEG）来研究精神分裂症不一致的双胞胎对中听觉皮层缺陷的遗传情况。
从总人口队列中招募精神分裂症不一致的单卵和双卵（MZ和DZ）双胞胎对以及人口统计学匹配的健康双胞胎对，测量他们对频繁标准音和偶尔偏差音的听觉EEG/MEG反应。将MEG/EEG结果与患者未受影响的MZ/DZ共同双胞胎和对照受试者（与精神分裂症患者的遗传相关性分别为1、0.5和0）与精神分裂症患者的遗传相似性进行回归分析。
精神分裂症患者的EEG反应P50、N100和失配负波（MMN）以及MEG反应P50m均降低。与对照受试者相比，他们未受影响的共同双胞胎中的P50和N100也显著降低。重要的是，P50和N100的降低与未受影响受试者与精神分裂症患者的遗传相似性相关。
我们的结果表明，精神分裂症中皮质听觉处理存在遗传异常，表现为P50/P50m和N100振幅降低，而MMN异常可能主要反映状态依赖性神经退行性变。
