Department of Psychiatry, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Republic of Korea.
Department of Psychology, Penn State University, Pennsylvania, USA.
Neuropsychopharmacol Rep. 2022 Mar;42(1):21-31. doi: 10.1002/npr2.12220. Epub 2021 Dec 10.
Vortioxetine has a positive effect on cognitive function in patients with major depressive disorder (MDD). This study aimed to examine the changes in cognitive function and EEG (spectral power and mismatch negativity (MMN)) in patients with MDD pre- and postvortioxetine treatment.
Thirty patients with MDD were included in the study. They were given vortioxetine (10-20mg po per day) for eight weeks. Depression and anxiety severities, social function (Korean version of the social adjustment scale (K-SAS)), and cognitive function (digit-symbol substitution Test (DSST), Korean version of the attentional control questionnaire (K-ACQ), and Korean version of the perceived deficits questionnaire for depression (K-PDQD)) were evaluated. Spectral power of EEG and MMN was also measured pre- and postvortioxetine treatment.
Depression and anxiety severity, social function, and cognitive functioning significantly improved after vortioxetine treatment. Also, there was a significant decrease in the right central delta band and an increase in the right central beta 2 band following vortioxetine treatment. The changes in EEG spectral power were not related to changes in cognitive functions. Baseline MMN significantly predicted changes in DSST score after controlling for the baseline clinical variables.
Vortioxetine treatment improved cognitive function and induced changes in EEG (decreased theta power and increased beta power) in patients with MDD. Our results suggest that greater negative MMN amplitude is associated with greater potential for cognitive improvement following vortioxetine treatment.
文拉法辛对伴有重性抑郁障碍（MDD）的患者的认知功能有积极影响。本研究旨在考察 MDD 患者经文拉法辛治疗前后认知功能和脑电图（频谱功率和失匹配负波（MMN））的变化。
本研究纳入 30 例 MDD 患者。他们接受文拉法辛（10-20mg po 每日一次）治疗 8 周。评估抑郁和焦虑严重程度、社会功能（韩国版社会适应量表（K-SAS））、认知功能（数字符号替代测验（DSST）、韩国版注意力控制问卷（K-ACQ）和韩国版抑郁感知缺陷问卷（K-PDQD））。治疗前后还测量了脑电图的频谱功率和 MMN。
文拉法辛治疗后，抑郁和焦虑严重程度、社会功能和认知功能显著改善。此外，文拉法辛治疗后右侧中央 delta 频段的功率降低，右侧中央 beta2 频段的功率增加。脑电图频谱功率的变化与认知功能的变化无关。控制基线临床变量后，基线 MMN 显著预测 DSST 评分的变化。
文拉法辛治疗改善了 MDD 患者的认知功能，并诱导了 EEG（theta 功率降低，beta 功率增加）的变化。我们的结果表明，更大的负 MMN 振幅与文拉法辛治疗后认知改善的潜力更大相关。
