Seif C, Bannowsky A, Wefer B, Naumann V C M, van der Horst C, Jünemann K-P, Braun P-M
Universitätsklinikum Schleswig-Holstein, Campus Kiel, Klinik für Urologie und Kinderurologie, Arnold-Heller-Strasse 7, 24105 Kiel.
Aktuelle Urol. 2006 Jul;37(4):277-80. doi: 10.1055/s-2005-919158.
Prior to implantation of a chronic sacral neurostimulator, it is important to establish which patients might profit from this kind of therapy in order to ensure, by means of a PNE (peripheral nerve evaluation) test, that the implantation of a permanent stimulating device is effective. In this study we compared the two different techniques used in our department (implantation of the permanent neurostimulation electrodes, the so-called "two-stage-implantation" vs. conventional PNE).
We performed a sacral nerve stimulation in 53 patients (mean age: 49.7 years, range: 14 - 75 years) over a minimum of 5 days. In 42 patients we performed a conventional PNE, 11 patients underwent "two-stage implantation" with implantation of the permanent electrodes.
52 of 53 patients received bilateral test stimulation (9 % at S2, 91 % at S3). One patient underwent unilateral PNE (S3) because of an anatomic deformity of the os sacrum. In 20 cases the conventional PNE-test (cPNE) was successful according to standard criteria (47.6 % of all cPNE). The response rate of "two-stage implantation" with implantation of the permanent electrodes was 81.8 % (9 of 11 patients).
The success rate of implantation of permanent neurostimulation electrodes in selecting patients for the permanent implant is significantly higher than the conventional PNE. In this group patients with neurogenic and overactive bladder dysfunctions showed the highest response rates to sacral nerve stimulation and are the most likely to benefit from sacral neuromodulation.
在植入慢性骶神经刺激器之前,确定哪些患者可能从这种治疗中获益非常重要,以便通过外周神经评估(PNE)测试确保永久性刺激装置的植入是有效的。在本研究中,我们比较了我们科室使用的两种不同技术(永久性神经刺激电极植入,即所谓的“两阶段植入”与传统PNE)。
我们对53例患者(平均年龄:49.7岁,范围:14 - 75岁)进行了至少5天的骶神经刺激。42例患者接受了传统PNE,11例患者进行了永久性电极植入的“两阶段植入”。
53例患者中有52例接受了双侧测试刺激(S2水平占9%,S3水平占91%)。1例患者因骶骨解剖畸形接受了单侧PNE(S3)。根据标准标准,20例传统PNE测试(cPNE)成功(占所有cPNE的47.6%)。永久性电极植入的“两阶段植入”的反应率为81.8%(11例患者中的9例)。
在为永久性植入选择患者时,永久性神经刺激电极的植入成功率显著高于传统PNE。在该组中,神经源性和膀胱过度活动性功能障碍患者对骶神经刺激的反应率最高,最有可能从骶神经调节中获益。