Sapronov N S, Fedotova Iu O, Losev N A
Eksp Klin Farmakol. 2006 May-Jun;69(3):10-3.
The effect of chronic (14 days) administration of the serotonin 5-HT(1A) receptors agonist 8-OH-DPAT (0.05 mg/kg, s.c.) and the 5-HT(1A) receptors antagonist NAN-190 (0.1 mg/kg, i.p.) alone or in combination with the acetylcholinesterase inhibitor galantamine (1.0 mg/kg, i.p.) on depression and anxiety was studied in old (24 months) male rats with dementia of Alzheimer's type. The results indicated that chronic combined administration of 8-OH-DPAT with galantamine resulted in pronounced antidepressant and anxiolytic action.
研究了在患有阿尔茨海默病型痴呆的老年（24个月）雄性大鼠中，单独或与乙酰胆碱酯酶抑制剂加兰他敏（1.0毫克/千克，腹腔注射）联合使用血清素5-HT(1A)受体激动剂8-OH-DPAT（0.05毫克/千克，皮下注射）和5-HT(1A)受体拮抗剂NAN-190（0.1毫克/千克，腹腔注射）14天对抑郁和焦虑的影响。结果表明，8-OH-DPAT与加兰他敏联合长期给药产生了明显的抗抑郁和抗焦虑作用。
