Findor J, Bruch Igartúa E, Sorda J, Jury R
Hospital de Clínicas José de San Martín (U.B.A.), Dto. de Medicina, Mar del Plata, Argentina.
Acta Gastroenterol Latinoam. 1991;21(2):115-9.
Three female patients with cholestatic jaundice related to methimazole therapy are presented. The jaundice appeared after more or less 30 days of therapy. Markers for hepatitis A and B were negative in all. None of them had previous history of alcoholism or ingestion of potentially hepatotoxic drugs. Characteristically there was a marked elevation of alkaline phosphatase and gamma-glutamyltranspeptidase with only moderate increase of the aminotransferases. Liver biopsy performed in all showed intensive cholestasis with low degree of inflammatory reaction confined to the portal tracts. The three patients presented a prolonged duration of the liver injury in spite of the interruption of the drug lasting in one of them up to one year, but all ultimately resolved.
本文报告了3例与甲巯咪唑治疗相关的胆汁淤积性黄疸女性患者。黄疸在治疗约30天后出现。所有患者甲型和乙型肝炎标志物均为阴性。她们均无酗酒史或服用潜在肝毒性药物史。其特征为碱性磷酸酶和γ-谷氨酰转肽酶显著升高，而转氨酶仅中度升高。所有患者的肝活检均显示重度胆汁淤积，炎症反应程度较轻，局限于门管区。尽管其中1例患者停药长达1年，但这3例患者的肝损伤持续时间均较长，但最终均痊愈。
