Kardos A, Földesi C, Nagy A, Sáringer A, Kiss A, Kiss G, Marschalkó P, Szabó M
Paediatric Intensive Care Unit, Heim Pál Children's Hospital, Ullöi Str. 89, 1086 Budapest, Hungary.
Acta Anaesthesiol Scand. 2006 Aug;50(7):869-74. doi: 10.1111/j.1399-6576.2006.01073.x.
Induction of anaesthesia may cause decreased cardiac output and blood pressure. Head-down tilt is often the first clinical step to treat hypotension. The objective of this randomized single centre study was to determine, with the use of impedance cardiography (ICG), whether Trendelenburg positioning modifies the haemodynamic response to propofol/fentanyl induction of anaesthesia in ASA I children.
Thirty ASA I children aged between 7 and 16 years scheduled for elective minor orthopaedic surgery were included. After intravenous induction with propofol and fentanyl in the head-down group (HDG, n = 15), 5 min of 20 degrees head-down tilt was applied. In the supine group (SG, n = 15), no change in the supine position was made. Heart rate (HR), mean arterial blood pressure (MABP), end-tidal carbon dioxide (ETCO(2)), stroke volume index (SVI), cardiac index (CI), systemic vascular resistance index (SVRI) and Heather index (HI) were recorded before (B), at 3 (A(3)), 5 (A(5)) and 8 (A(8)) minutes after induction in each group.
After induction, a significant decrease in CI, MABP, HR and HI was recorded in both groups. In the study group, significantly lower values of HR (66 vs. 78 beat/min) and higher values of SVI (42.9 vs. 40.6 ml/min/m(2)) were measured at A(3) compared with the control group. After induction, no difference in CI and SVRI was found between the two groups.
The present study shows that cardiac performance is not improved by Trendelenburg positioning after propofol/fentanyl induction of anaesthesia in children.
麻醉诱导可能导致心输出量和血压下降。头低位倾斜通常是治疗低血压的首要临床措施。本随机单中心研究的目的是,使用阻抗心动图(ICG)来确定头低位倾斜是否会改变美国麻醉医师协会(ASA)I级儿童在丙泊酚/芬太尼麻醉诱导时的血流动力学反应。
纳入30例计划进行择期小型骨科手术、年龄在7至16岁之间的ASA I级儿童。头低位组(HDG,n = 15)静脉注射丙泊酚和芬太尼诱导麻醉后,进行5分钟20度的头低位倾斜。仰卧位组(SG,n = 15)则保持仰卧位不变。记录每组诱导前(B)、诱导后3分钟(A(3))、5分钟(A(5))和8分钟(A(8))时的心率(HR)、平均动脉压(MABP)、呼气末二氧化碳分压(ETCO₂)、每搏量指数(SVI)、心脏指数(CI)、全身血管阻力指数(SVRI)和希瑟指数(HI)。
诱导后,两组的CI、MABP、HR和HI均显著下降。与对照组相比,研究组在A(3)时HR显著降低(66次/分钟 vs. 78次/分钟),SVI显著升高(42.9 ml/min/m² vs. 40.6 ml/min/m²)。诱导后,两组的CI和SVRI无差异。
本研究表明,儿童在丙泊酚/芬太尼麻醉诱导后采用头低位倾斜并不能改善心脏功能。