一种由菲咯啉铜共轭物与含N-甲基咪唑环的聚酰胺组成的新型复合物实现的位点选择性DNA切割。
Site-selective DNA cleavage by a novel complex of copper-conjugate of Phen and polyamide containing N-methylimidazole rings.
作者信息
Liu Dan, Zhou Jiang, Li Huihui, Zheng Bo, Yuan Gu
机构信息
Beijing National Laboratory for Molecular Sciences, Department of Chemical Biology, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.
出版信息
Bioorg Med Chem Lett. 2006 Oct 1;16(19):5032-5. doi: 10.1016/j.bmcl.2006.07.049. Epub 2006 Aug 1.
PMID:16879963
Abstract
A novel conjugate of 3-Clip-Phen and polyamide containing three N-methylimidazole (Im) rings was synthesized for the targeting human telomeric repeat of 5'-TTAGGG-3', and the DNA cleaving activity and the sequence selectivity of the complex of copper-conjugate were confirmed by electrospray ionization mass spectrometry.
摘要
合成了一种含三个N-甲基咪唑（Im）环的3-Clip-Phen与聚酰胺的新型共轭物，用于靶向人端粒重复序列5'-TTAGGG-3'，并通过电喷雾电离质谱法证实了铜共轭物复合物的DNA切割活性和序列选择性。
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