Mancia G, Grassi G
Istituto di Clinica Medica Generale e Terapia Medica, Università di Milano, Italy.
Clin Auton Res. 1991 Sep;1(3):245-9. doi: 10.1007/BF01824995.
Evaluation of sympathetic cardiovascular influences has important physiological, pathophysiological and clinical implications. This paper reviews some of the methods employed to measure these influences in man, along with their advantages and disadvantages. The most useful methods appear to be the measurement of plasma noradrenaline (particularly when modified to calculate spillover rate of noradrenaline) and direct recording of sympathetic nerve traffic. With the former, despite the technological advances in measurement, certain methodological problems remain, such as the separation of noradrenaline secretion from clearance. With the latter technique peripheral muscle and skin sympathetic activity can be measured separately but the question of regional vascular variability has still to be resolved. A combination of these two methods may represent the ideal approach. This review considers the complex problems associated with attempts to precisely quantify sympathetic cardiovascular influences in man.
评估交感神经对心血管系统的影响具有重要的生理、病理生理及临床意义。本文综述了一些用于测量人体交感神经对心血管系统影响的方法，以及这些方法的优缺点。最有用的方法似乎是测量血浆去甲肾上腺素（特别是经过改良以计算去甲肾上腺素溢出率时）和直接记录交感神经活动。对于前者，尽管测量技术取得了进展，但仍存在一些方法学问题，例如去甲肾上腺素分泌与清除的分离。对于后一种技术，可以分别测量外周肌肉和皮肤的交感神经活动，但区域血管变异性的问题仍有待解决。这两种方法的结合可能是理想的方法。本文探讨了在人体中精确量化交感神经对心血管系统影响的尝试所涉及的复杂问题。
