在存在抗I型菌毛抗体的情况下，阻断尿路致病性大肠杆菌分离株对HEP-2细胞和小鼠膀胱的黏附。
Blocking adherence of uropathogenic Escherichia coli isolate to HEP-2 cells and bladder of mice in the presence of antibody against p-fimbriae.
作者信息
Bidhendi S Moradi, Sattari M, Pourbakhsh S A, Mobarez A, Vandyousefi J, Khaki P, Heidari M H, Kazemnejad A
机构信息
Bacteriology Department, Tarbiat Modarres University, Tehran, Iran.
出版信息
Biologicals. 2007 Apr;35(2):99-105. doi: 10.1016/j.biologicals.2006.03.012. Epub 2006 Jul 31.
Presence of fimbriae on Escherichia coli isolated from the urine of patients with urinary tract infection was related to the ability of the bacteria to attach to human uroepithelial cells. One of the 50 isolates that expresses high MRHA p-fimbriae, selected and antibody against p-fimbriae from it, showed blocking of attachment of bacteria to HEP-2 cell in 1:1024 titer. Also, 1:512 titer of this antiserum to blocking of attachment in bladder tissue of mice is significant.
从尿路感染患者尿液中分离出的大肠杆菌上菌毛的存在与细菌附着于人尿道上皮细胞的能力有关。在50株表达高甘露糖抗性血凝素（MRHA）菌毛的分离株中，挑选出一株并制备其菌毛抗体，该抗体在1:1024效价时可阻断细菌与HEP-2细胞的附着。此外，该抗血清在1:512效价时对小鼠膀胱组织中细菌附着的阻断作用也很显著。
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