Stetson Daniel B, Medzhitov Ruslan
Howard Hughes Medical Institute, Yale University School of Medicine, CT 06520, USA.
J Exp Med. 2006 Aug 7;203(8):1837-41. doi: 10.1084/jem.20061377. Epub 2006 Jul 31.
Mice lacking the adaptor protein that initiates an antiviral response downstream of the RNA helicases retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5) have recently been described. These studies highlight the essential and nonredundant role of nucleic acid recognition in the induction of type I interferon production and raise important questions regarding the nature of cell-autonomous virus detection in coordinating the antiviral response.
最近报道了缺乏衔接蛋白的小鼠，该衔接蛋白在RNA解旋酶维甲酸诱导基因I（RIG-I）和黑色素瘤分化相关基因5（MDA5）下游启动抗病毒反应。这些研究突出了核酸识别在诱导I型干扰素产生中的重要且不可替代的作用，并就协调抗病毒反应中细胞自主病毒检测的本质提出了重要问题。
