一所大学医院对187名类风湿性关节炎男性患者进行随访，观察骨质疏松症的发病频率。

Frequency of osteoporosis in 187 men with rheumatoid arthritis followed in a university hospital.

作者信息

Nolla Joan M, Roig-Vilaseca Daniel, Gomez-Vaquero Carmen, Mateo Lourdes, Juanola Xavier, Rodriguez-Moreno Jesús, Narvaez Javier, Valverde Josep

机构信息

Rheumatology Department, IDIBELL-Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain.

出版信息

J Rheumatol. 2006 Aug;33(8):1472-5.

PMID:16881105

Abstract

OBJECTIVE

Although there is relevant information on frequency of osteoporosis in women with rheumatoid arthritis (RA), data about male patients are limited. We evaluated the frequency of osteoporosis in a group of Spanish men with RA followed in a university hospital.

METHODS

From the database of our bone densitometry unit, we searched for men with RA evaluated between January 1991 and December 2004 and identified 187 patients, 156 of whom were older than 50 years. Previously recorded demographic, disease, and treatment-related variables were collected. Bone mineral density (BMD) was measured by dual x-ray absorptiometry (DEXA). Osteoporosis was defined according to the criteria of the World Health Organization (WHO), recommended for postmenopausal Caucasian women, as a T score <or= -2.5 SD, and the International Society for Clinical Densitometry (ISCD), which indicates the same diagnostic threshold, but only in men over age 50 years.

RESULTS

BMD was lower than in the general population in both lumbar spine [Z score -0.41 +/- 1.00 (95% CI -0.55 to -0.26)] and femoral neck [Z score -0.46 +/- 0.95 (95% CI -0.60 to -0.31)]. When the WHO threshold for postmenopausal women was applied, frequency of osteoporosis was 13% at lumbar spine, 12% at the femoral neck, and 21% in at least one of the evaluated sites. When ISCD criteria were applied, the frequency of osteoporosis was 13%, 14%, and 23%, respectively.

CONCLUSION

Frequency of osteoporosis in men is considerably lower than that traditionally established in women with RA, independent of the diagnostic criteria applied.

摘要

目的

虽然有关于类风湿关节炎（RA）女性患者骨质疏松症发生率的相关信息，但关于男性患者的数据有限。我们评估了在一家大学医院随访的一组西班牙男性RA患者中骨质疏松症的发生率。

方法

从我们骨密度测量科室的数据库中，搜索1991年1月至2004年12月期间接受评估的男性RA患者，共识别出187例患者，其中156例年龄超过50岁。收集先前记录的人口统计学、疾病和治疗相关变量。采用双能X线吸收法（DEXA）测量骨密度（BMD）。骨质疏松症根据世界卫生组织（WHO）为绝经后白种女性推荐的标准定义为T值≤ -2.5标准差，国际临床骨密度测量学会（ISCD）也指出相同的诊断阈值，但仅适用于50岁以上男性。

结果

腰椎[Z值 -0.41 ± 1.00（95%可信区间 -0.55至 -0.26）]和股骨颈[Z值 -0.46 ± 0.95（95%可信区间 -0.60至 -0.31）]的骨密度均低于一般人群。当应用WHO绝经后女性的阈值时，腰椎骨质疏松症发生率为13%，股骨颈为12%，至少一个评估部位为21%。当应用ISCD标准时，骨质疏松症发生率分别为13%、14%和23%。