Cavallo G P, Cavallo R
Istituto Policattedra di Clinica Otorinolaringoiatrica dell'Università di Torino.
G Batteriol Virol Immunol. 1991 Jan-Dec;84(1-12):107-24.
The division of T cells into distinct subsets (Th-1 and Th-2), based upon cytokine production, is a major advance in understanding the immune reactivities particularly those associated with allergy. This report summarizes some of the highlights on pathogenesis of allergic rhinitis. Th-2 cells, driven by IL-4, play an important role in allergic reactions inducing IgE switching in B cells and proliferation of mastocytes. In addition, by interaction with IL-5, Th-2 lymphocytes promotes eosinophil growth. By contrast, Th-1 cells antagonize Th-2 activity by IFN-gamma production. Finally IL-10, produced by Th-2, blocks the effects of the cytokines elaborated by Th-1. Recent results of this rapidly expanding area of research provide the background for this review. The intricate connections between Th-1, Th-2, the endothelial cells of the nose vessels and stromal cells are discussed.
基于细胞因子的产生将T细胞分为不同亚群（Th-1和Th-2），这是理解免疫反应性尤其是与过敏相关的免疫反应性方面的一项重大进展。本报告总结了变应性鼻炎发病机制的一些要点。由白细胞介素-4驱动的Th-2细胞在诱导B细胞发生IgE类别转换和肥大细胞增殖的过敏反应中起重要作用。此外，通过与白细胞介素-5相互作用，Th-2淋巴细胞促进嗜酸性粒细胞生长。相比之下，Th-1细胞通过产生γ干扰素拮抗Th-2活性。最后，由Th-2产生的白细胞介素-10可阻断Th-1所产生细胞因子的作用。这一迅速扩展的研究领域的最新成果为本次综述提供了背景。文中讨论了Th-1、Th-2、鼻血管内皮细胞和基质细胞之间的复杂联系。
