Gnad Florian, Parsch John
Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany.
Bioinformatics. 2006 Oct 15;22(20):2577-9. doi: 10.1093/bioinformatics/btl422. Epub 2006 Jul 31.
We describe Sebida, a database of genes with sex-biased expression. The database integrates results from multiple, independent microarray studies comparing male and female gene expression in Drosophila melanogaster, Drosophila simulans and Anopheles gambiae. Sebida uses standard nomenclature, which allows individual genes to be compared across different microarray platforms and to be queried by gene name, symbol, or annotation number. In addition to ratios of male/female expression for each gene, Sebida also contains information useful for evolutionary studies, such as local recombination rate, degree of codon bias and interspecific divergence at synonymous and non-synonymous sites.
Sebida can be accessed at http://www.sebida.de
我们描述了Sebida，一个具有性别偏向性表达的基因数据库。该数据库整合了多项独立微阵列研究的结果，这些研究比较了黑腹果蝇、拟果蝇和冈比亚按蚊中雄性和雌性的基因表达。Sebida使用标准命名法，这使得单个基因能够在不同的微阵列平台之间进行比较，并可以通过基因名称、符号或注释编号进行查询。除了每个基因的雄性/雌性表达比率外，Sebida还包含对进化研究有用的信息，如局部重组率、密码子偏向程度以及同义位点和非同义位点的种间差异。
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