Kamenskaya M A, Elmqvist D, Thesleff S
Arch Neurol. 1975 Aug;32(8):510-8. doi: 10.1001/archneur.1975.00490500030002.
The effect of guanidine on the neuromuscular transmission in human intercostal and mouse diaphragm muscle in vitro during repetitive nerve stimulation was studied. The drug greatly increased the release of acetylcholine (ACh) quanta by nerve impulses at low frequencies of nerve stimulation and at the beginning of tetani at high frequencies of stimulation. The effect was shown to be produced by an increase in fractional release from an unchanged store of ACh quanta available fro immediate release. This seems to explain why guanidine has a poor therapeutic effect in myasthenia gravis but a good effect in the myasthenic syndrome.
研究了胍对体外人肋间肌和小鼠膈肌在重复神经刺激期间神经肌肉传递的影响。在低频神经刺激以及高频刺激强直收缩开始时，该药物通过神经冲动大幅增加了乙酰胆碱（ACh）量子的释放。结果表明，这种效应是由可立即释放的ACh量子未改变的储存库中分数释放增加所产生的。这似乎解释了为什么胍对重症肌无力的治疗效果不佳，但对肌无力综合征却有良好效果。
