重组微生物中白藜芦醇的生产。
Production of resveratrol in recombinant microorganisms.
作者信息
Beekwilder Jules, Wolswinkel Rianne, Jonker Harry, Hall Robert, de Vos C H Ric, Bovy Arnaud
机构信息
Plant Research International, 6700 AA Wageningen, The Netherlands.
出版信息
Appl Environ Microbiol. 2006 Aug;72(8):5670-2. doi: 10.1128/AEM.00609-06.
Abstract
Resveratrol production in Saccharomyces cerevisiae was compared to that in Escherichia coli. In both systems, 4-coumarate:coenzyme A ligase from tobacco and stilbene synthase from grapes were expressed. When p-coumaric acid was used as the precursor, resveratrol accumulations in the culture medium were observed to be comparable in E. coli (16 mg/liter) and yeast (6 mg/liter).
摘要
对酿酒酵母中白藜芦醇的产量与大肠杆菌中的产量进行了比较。在这两种系统中，均表达了来自烟草的4-香豆酸：辅酶A连接酶和来自葡萄的芪合酶。当使用对香豆酸作为前体时，观察到大肠杆菌（16毫克/升）和酵母（6毫克/升）在培养基中的白藜芦醇积累量相当。
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