Madhavan Aravind, Arun K B, Alex Deepthy, Anoopkumar A N, Emmanual Shibitha, Chaturvedi Preeti, Varjani Sunita, Tiwari Archana, Kumar Vinod, Reshmy R, Awasthi Mukesh Kumar, Binod Parameswaran, Aneesh Embalil Mathachan, Sindhu Raveendran
Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, 695014 India.
Department of Biotechnology, Mar Ivanios College, Trivandrum, Kerala 695015 India.
J Food Sci Technol. 2023 Aug;60(8):2092-2104. doi: 10.1007/s13197-022-05482-5. Epub 2022 Jun 18.
Nutraceuticals have attained substantial attention due to their health-boosting or disease-prevention characteristics. Growing awareness about the potential of nutraceuticals for the prevention and management of diseases affecting human has led to an increase in the market value of nutraceuticals in several billion dollars. Nevertheless, limitations in supply and isolation complications from plants, animals or fungi, limit the large-scale production of nutraceuticals. Microbial engineering at metabolic level has been proved as an environment friendly substitute for the chemical synthesis of nutraceuticals. Extensively used microbial systems such as and have been modified as versatile cell factories for the synthesis of diverse nutraceuticals. This review describes current interventions in metabolic engineering for synthesising some of the therapeutically important nutraceuticals (phenolic compounds, polyunsaturated fatty acids and carotenoids). We focus on the interventions in enhancing product yield through engineering at gene level or pathway level.
营养保健品因其促进健康或预防疾病的特性而备受关注。人们越来越意识到营养保健品在预防和管理影响人类的疾病方面的潜力，这导致营养保健品的市场价值增加了数十亿美元。然而，植物、动物或真菌来源的营养保健品在供应方面存在限制以及分离复杂，限制了其大规模生产。代谢水平的微生物工程已被证明是营养保健品化学合成的一种环境友好型替代方法。广泛使用的微生物系统，如[具体微生物系统1]和[具体微生物系统2]，已被改造为用于合成多种营养保健品的通用细胞工厂。本综述描述了目前在代谢工程中为合成一些具有重要治疗意义的营养保健品（酚类化合物、多不饱和脂肪酸和类胡萝卜素）所采取的干预措施。我们重点关注通过基因水平或途径水平的工程改造来提高产品产量的干预措施。
