分枝杆菌特异性基因Rv2719c是一种不依赖RecA的DNA损伤诱导基因。
The mycobacterium-specific gene Rv2719c is DNA damage inducible independently of RecA.
作者信息
Brooks Patricia C, Dawson Lisa F, Rand Lucinda, Davis Elaine O
机构信息
Division of Mycobacterial Research, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW71AA, United Kingdom.
出版信息
J Bacteriol. 2006 Aug;188(16):6034-8. doi: 10.1128/JB.00340-06.
Abstract
The mycobacterium-specific gene Rv2719c was found to be expressed primarily from a promoter that was clearly DNA damage inducible independently of RecA. Upstream of the transcriptional start site for this promoter, sequence motifs resembling those observed previously at the RecA-independent, DNA damage-inducible recA promoter were identified, and the -10 motif was demonstrated by mutational analysis in transcriptional fusion constructs to be important for expression of Rv2719c.
摘要
发现分枝杆菌特异性基因Rv2719c主要从一个启动子表达，该启动子明显可被DNA损伤诱导，且不依赖RecA。在该启动子转录起始位点上游，鉴定出了与先前在不依赖RecA的DNA损伤诱导型recA启动子处观察到的序列基序相似的序列基序，并且通过转录融合构建体中的突变分析表明，-10基序对于Rv2719c的表达很重要。
相似文献
1
The mycobacterium-specific gene Rv2719c is DNA damage inducible independently of RecA.
J Bacteriol. 2006 Aug;188(16):6034-8. doi: 10.1128/JB.00340-06.
2
DNA damage induction of recA in Mycobacterium tuberculosis independently of RecA and LexA.
Mol Microbiol. 2002 Nov;46(3):791-800. doi: 10.1046/j.1365-2958.2002.03199.x.
3
Identification of a promoter motif regulating the major DNA damage response mechanism of Mycobacterium tuberculosis.
FEMS Microbiol Lett. 2004 Sep 1;238(1):57-63. doi: 10.1016/j.femsle.2004.07.017.
4
Enhanced expression of recX in Mycobacterium tuberculosis owing to a promoter internal to recA.
Tuberculosis (Edinb). 2011 Mar;91(2):127-35. doi: 10.1016/j.tube.2010.11.002. Epub 2011 Jan 19.
5
Characterization of the two Mycobacterium tuberculosis recA promoters.
J Bacteriol. 2003 Oct;185(20):6005-15. doi: 10.1128/JB.185.20.6005-6015.2003.
6
Determination of DNA sequences required for regulated Mycobacterium tuberculosis RecA expression in response to DNA-damaging agents suggests that two modes of regulation exist.
J Bacteriol. 1997 Jun;179(11):3509-18. doi: 10.1128/jb.179.11.3509-3518.1997.
7
Transcriptional analysis of the recA gene in Streptomyces rimosus: identification of the new type of promoter.
FEMS Microbiol Lett. 2002 Mar 19;209(1):133-7. doi: 10.1111/j.1574-6968.2002.tb11121.x.
8
Functional analysis of the recA promoter of Rhodobacter capsulatus.
Mol Gen Genet. 1997 Aug;255(5):487-94. doi: 10.1007/s004380050521.
9
The role of multiple SOS boxes upstream of the Mycobacterium tuberculosis lexA gene--identification of a novel DNA-damage-inducible gene.
Microbiology (Reading). 2002 Nov;148(Pt 11):3609-3615. doi: 10.1099/00221287-148-11-3609.
10
ClpR protein-like regulator specifically recognizes RecA protein-independent promoter motif and broadly regulates expression of DNA damage-inducible genes in mycobacteria.
J Biol Chem. 2011 Sep 9;286(36):31159-67. doi: 10.1074/jbc.M111.241802. Epub 2011 Jul 19.
引用本文的文献
1
Simultaneous occurrence of invasive pulmonary aspergillosis and diffuse large B-cell lymphoma: case report and literature review.
BMC Cancer. 2020 Jan 6;20(1):15. doi: 10.1186/s12885-019-6471-x.
2
Regulation of Cell Division in Bacteria by Monitoring Genome Integrity and DNA Replication Status.
J Bacteriol. 2020 Jan 2;202(2). doi: 10.1128/JB.00408-19.
3
The masquerading splenic lesion.
Indian J Med Paediatr Oncol. 2016 Oct-Dec;37(4):311-313. doi: 10.4103/0971-5851.195728.
4
Simultaneous occurrence of Hodgkin's disease and tubercular lymphadenitis in the same cervical lymph node: a rare presentation.
BMJ Case Rep. 2016 Jan 6;2016:bcr2015213355. doi: 10.1136/bcr-2015-213355.
5
A case of concomitant Hodgkin's lymphoma with tuberculosis.
Lung India. 2014 Jan;31(1):59-62. doi: 10.4103/0970-2113.125985.
6
Global analysis of the regulon of the transcriptional repressor LexA, a key component of SOS response in Mycobacterium tuberculosis.
J Biol Chem. 2012 Jun 22;287(26):22004-14. doi: 10.1074/jbc.M112.357715. Epub 2012 Apr 23.
7
A TetR-like regulator broadly affects the expressions of diverse genes in Mycobacterium smegmatis.
Nucleic Acids Res. 2012 Feb;40(3):1009-20. doi: 10.1093/nar/gkr830. Epub 2011 Oct 5.
8
ClpR protein-like regulator specifically recognizes RecA protein-independent promoter motif and broadly regulates expression of DNA damage-inducible genes in mycobacteria.
J Biol Chem. 2011 Sep 9;286(36):31159-67. doi: 10.1074/jbc.M111.241802. Epub 2011 Jul 19.
9
YneA, an SOS-induced inhibitor of cell division in Bacillus subtilis, is regulated posttranslationally and requires the transmembrane region for activity.
J Bacteriol. 2010 Jun;192(12):3159-73. doi: 10.1128/JB.00027-10. Epub 2010 Apr 16.
10
RecA-independent DNA damage induction of Mycobacterium tuberculosis ruvC despite an appropriately located SOS box.
J Bacteriol. 2010 Jan;192(2):599-603. doi: 10.1128/JB.01066-09. Epub 2009 Nov 13.
本文引用的文献
1
Transcription activation of a UV-inducible Clostridium perfringens bacteriocin gene by a novel sigma factor.
Mol Microbiol. 2005 Feb;55(4):1196-206. doi: 10.1111/j.1365-2958.2004.04456.x.
2
Identification of a promoter motif regulating the major DNA damage response mechanism of Mycobacterium tuberculosis.
FEMS Microbiol Lett. 2004 Sep 1;238(1):57-63. doi: 10.1016/j.femsle.2004.07.017.
3
Heat and DNA damage induction of the LexA-like regulator HdiR from Lactococcus lactis is mediated by RecA and ClpP.
Mol Microbiol. 2003 Oct;50(2):609-21. doi: 10.1046/j.1365-2958.2003.03713.x.
4
The majority of inducible DNA repair genes in Mycobacterium tuberculosis are induced independently of RecA.
Mol Microbiol. 2003 Nov;50(3):1031-42. doi: 10.1046/j.1365-2958.2003.03765.x.
5
Characterization of the two Mycobacterium tuberculosis recA promoters.
J Bacteriol. 2003 Oct;185(20):6005-15. doi: 10.1128/JB.185.20.6005-6015.2003.
6
LexA-independent DNA damage-mediated induction of gene expression in Myxococcus xanthus.
Mol Microbiol. 2003 Aug;49(3):769-81. doi: 10.1046/j.1365-2958.2003.03592.x.
7
The role of multiple SOS boxes upstream of the Mycobacterium tuberculosis lexA gene--identification of a novel DNA-damage-inducible gene.
Microbiology (Reading). 2002 Nov;148(Pt 11):3609-3615. doi: 10.1099/00221287-148-11-3609.
8
A new regulatory DNA motif of the gamma subclass Proteobacteria: identification of the LexA protein binding site of the plant pathogen Xylella fastidiosa.
Microbiology (Reading). 2002 Nov;148(Pt 11):3583-3597. doi: 10.1099/00221287-148-11-3583.
9
DNA damage induction of recA in Mycobacterium tuberculosis independently of RecA and LexA.
Mol Microbiol. 2002 Nov;46(3):791-800. doi: 10.1046/j.1365-2958.2002.03199.x.
10
Definition of the mycobacterial SOS box and use to identify LexA-regulated genes in Mycobacterium tuberculosis.
J Bacteriol. 2002 Jun;184(12):3287-95. doi: 10.1128/JB.184.12.3287-3295.2002.
Zotero 插件