Cananäu S A, Groza P, Albu A, Dragomir C T, Petrescu A, Zaharia B
Aviat Space Environ Med. 1975 Jul;46(7):916-21.
The present paper refers to the activity of some enzymes associated with the cellular cytomembranes in the plasma and brain of guinea pigs exposed to the action of repeated +10Gz acceleration. Immediately after the last run, diminution of enzymatic activity in the brain supernate ran parralel to a rise in plasma enzymatic activity. Variations in enzymatic activity suggested the liberation of enzymes connected with the neuronal organelles, perhaps consequent to alterations in the permeability or structure of the neuronal cytomembranes. These alterations might also be interpreted as being accompanied by permeabilization of the blood-brain barrier, with release of enzymes from the neuronal structures into the plasma. Changes in the permeability of the neuronal membranes might be attributed to several factors: cerebral hypoxia following the hemodynamic and ventilation alterations induced by hypergravitation, the influence upon the membrane permeability of hormones released in excess under the stress of acceleration, and the strain to which the central nervous system neurones are subjected by the multitude of afferent impulses with a starting point in the various types of receptors stimulated by hypergravitation.
本文研究了豚鼠在反复受到+10Gz加速度作用后，其血浆和大脑中与细胞膜相关的一些酶的活性。在最后一次实验后立即发现，脑匀浆上清液中酶活性的降低与血浆中酶活性的升高平行。酶活性的变化表明与神经元细胞器相关的酶被释放出来，这可能是由于神经元细胞膜通透性或结构的改变所致。这些改变也可以解释为血脑屏障通透性增加，导致酶从神经元结构释放到血浆中。神经元膜通透性的变化可能归因于几个因素：超重引起的血流动力学和通气改变导致的脑缺氧、加速度应激下过量释放的激素对膜通透性的影响，以及中枢神经系统神经元因超重刺激多种类型受体产生的大量传入冲动而受到的应变。
