Owen M J, Mullan M J
Department of Biochemistry and Molecular Genetics, St Mary's Hospital Medical School, London, UK.
Trends Neurosci. 1990 Jan;13(1):29-31. doi: 10.1016/0166-2236(90)90059-j.
The application of molecular genetics to the study of mental disorders has begun in earnest. Most of the initial interest has focused on the functional psychoses as these common and debilitating disorders have long been known to have a significant genetic component. A number of groups have now reported data from RFLP linkage studies of both schizophrenia and bipolar affective disorder (manic-depression). Unfortunately the results are already conflicting with early findings of linkage unconfirmed by subsequent studies.
分子遗传学在精神障碍研究中的应用已正式启动。最初的大部分兴趣集中在功能性精神病上，因为这些常见且使人衰弱的疾病长期以来就被认为具有重要的遗传成分。现在有一些研究小组报告了关于精神分裂症和双相情感障碍（躁狂抑郁症）的限制性片段长度多态性（RFLP）连锁研究数据。不幸的是，这些结果已经与早期连锁研究结果相矛盾，后续研究并未证实早期发现。
