在帕金森病大鼠模型中对年轻、老龄及去势雄性大鼠进行垂体腺苷酸环化酶激活肽（PACAP）作用的比较研究。

Comparative study of the effects of PACAP in young, aging, and castrated males in a rat model of Parkinson's disease.

作者信息

Reglódi D, Tamás A, Lengvári I, Toth G, Szalontay L, Lubics A

机构信息

Department of Anatomy, University of Pécs, 7624 Pécs, Szigeti u 12. Hungary.

出版信息

Ann N Y Acad Sci. 2006 Jul;1070:518-24. doi: 10.1196/annals.1317.072.

DOI:10.1196/annals.1317.072

PMID:16888218

Abstract

We have previously shown that PACAP ameliorates the neurological symptoms and reduces the dopaminergic cell loss in young male rats, in a 6-hydroxydopamine (6-OHDA)-induced lesion of the substantia nigra, a model of Parkinson's disease. In the present study, we compared the effects of PACAP in young, aging, and castrated males. Our results show that PACAP significantly reduced the dopaminergic cell loss in young and aging males. In castrated males, 6-OHDA did not induce such a severe cell loss, and it was not altered by PACAP. However, PACAP effectively ameliorated behavioral symptoms in all groups, with a degree of recovery depending on age and endocrine status.

摘要

我们之前已经表明，在6-羟基多巴胺（6-OHDA）诱导的黑质损伤（一种帕金森病模型）中，垂体腺苷酸环化酶激活肽（PACAP）可改善年轻雄性大鼠的神经症状并减少多巴胺能细胞损失。在本研究中，我们比较了PACAP对年轻、老龄和去势雄性大鼠的影响。我们的结果表明，PACAP显著减少了年轻和老龄雄性大鼠的多巴胺能细胞损失。在去势雄性大鼠中，6-OHDA并未诱导如此严重的细胞损失，且PACAP对其没有影响。然而，PACAP有效改善了所有组的行为症状，恢复程度取决于年龄和内分泌状态。