Watanabe Jun, Ohno Fusako, Shioda Seiji, Kikuyama Sakae, Nakaya Kazuyasu, Nakajo Shigeo
Laboratory of Biochemistry, Yokohama College of Pharmacy, 601 Matanocho, Totsuka-Ku, Yokohama, Kanagawa 245-0066, Japan.
Ann N Y Acad Sci. 2006 Jul;1070:597-601. doi: 10.1196/annals.1317.090.
Expression of members of the conventional protein kinase C (cPKC) family in the differentiation of mouse neural stem cells (NSCs) induced by pituitary adenylate cyclase-activating polypeptide (PACAP) was investigated. In particular, expression of the alpha and beta subtypes of cPKC in NSCs was observed. In response to activation by PACAP, cPKCbeta transiently increased twofold by day 2 and returned to basal levels by day 4, suggesting that cPKCbeta might be responsible for the differentiation process.
研究了传统蛋白激酶C（cPKC）家族成员在垂体腺苷酸环化酶激活多肽（PACAP）诱导的小鼠神经干细胞（NSC）分化中的表达。特别地，观察到了NSC中cPKC的α和β亚型的表达。响应于PACAP的激活，cPKCβ在第2天短暂增加两倍，并在第4天恢复到基础水平，这表明cPKCβ可能负责分化过程。
