Koriakova N N, Rozhdestvenskaia E D, Kazantseva S V, Bushueva T V, Valamina I E
Ter Arkh. 2006;78(5):14-7.
To specify the cytokine profile in chronic glomerulonephritis (CGN) with aggravating renal function, to assess prognostic value of some cytokines in development of CGN in these patients.
Indices of the cytokine profile were followed up in 56 CGN patients with nephrotic syndrome and arterial hypertension and compared in those patients who developed CGN for 2 years (group 2) versus patients with intact renal function (group 1).
Serum levels of IL-1beta and TNF-alpha were maximal in CGN patients with aggravating renal function. Such patients had a low concentration of serum IL-1beta receptors antagonists. Severity of proteinurea correlated with serum level of TNF-alpha. If the latter was higher than 120 pg/ml, there was a high probability of CRF development within 2 years.
Pathogenesis of CRF in CGN is associated with proinflammatory cytokines, especially TNF-alpha. Its serum concentration can be used for evaluating risk of renal function deterioration.
明确肾功能恶化的慢性肾小球肾炎（CGN）患者的细胞因子谱，评估某些细胞因子对这些患者CGN病情发展的预后价值。
对56例患有肾病综合征和动脉高血压的CGN患者的细胞因子谱指标进行随访，并将病程达2年的CGN患者（第2组）与肾功能正常的患者（第1组）进行比较。
肾功能恶化的CGN患者血清白细胞介素-1β（IL-1β）和肿瘤坏死因子-α（TNF-α）水平最高。这类患者血清IL-1β受体拮抗剂浓度较低。蛋白尿的严重程度与血清TNF-α水平相关。若TNF-α高于120 pg/ml，2年内发生慢性肾衰竭（CRF）的可能性很大。
CGN中CRF的发病机制与促炎细胞因子尤其是TNF-α有关。其血清浓度可用于评估肾功能恶化风险。
