Sun Chaohong, Hajduk Philip J
Abbott Laboratories, R46Y, AP-IO, 100 Abbott Park Road, Abbott Park, IL 60064-3500, USA.
Curr Opin Drug Discov Devel. 2006 Jul;9(4):463-70.
Nuclear magnetic resonance (NMR) has matured as an important tool in drug discovery and development, with firm establishment of its roles in lead generation and optimization through application of NMR-based fragment screening and structure-based drug design. Besides these applications, NMR technology has expanded to make contributions both earlier and later in the drug discovery process. This review will focus on the impact of NMR in the early stages of drug discovery, in particular in characterizing the viability of targets for further discovery exercises and improving high-throughput screening through compound file-enhancement initiatives.
核磁共振（NMR）已发展成为药物发现与开发中的一项重要工具，通过基于核磁共振的片段筛选和基于结构的药物设计，其在先导化合物生成和优化中的作用得以稳固确立。除了这些应用，NMR技术已得到扩展，在药物发现过程的早期和后期均有所贡献。本综述将聚焦于NMR在药物发现早期阶段的影响，特别是在确定进一步发现工作的靶点可行性以及通过化合物库增强计划改进高通量筛选方面的影响。
