Barragán-Meijueiro M M, Morfín-Maciel B, Nava-Ocampo A A
Colegio Mexicano de Pediatras con Especialidad en Alergia e Inmunología Clínica, Coyoacan, Mexico.
J Investig Allergol Clin Immunol. 2006;16(4):247-52.
There is some evidence suggesting a link between paracetamol exposure and atopy in both adults and children.
We aimed to investigate whether further epidemiological support for a link between paracetamol intake and allergy could be found in a population of Mexican children.
In a cross-sectional study design, we applied the ISAAC questionnaire to 3493 children aged 6 to 7 years old. Two analyses were performed: (1) children were classified as cases if they had wheezing, rhinitis, or eczema at any time from their neonatal period up until they reached the age of 6 to 7 years, or as controls if they had never experienced these conditions, and (2) children were classified as cases if they had wheezing, rhinitis, or eczema in the 12 months prior to the study. Paracetamol intake was considered positive if it frequently occurred during the first year of life (first analysis) or in the last 12 months (second analysis).
Paracetamol intake in the first year of life was significantly associated with an increased risk of ev having wheezing (adjusted odds ratio [OR], 1.69; 95% confidence interval [CI], 1.23 to 2.34) and rhinitis (adjusted OR, 1.37; 95% CI, 1.20 to 1.59) but not eczema (adjusted OR, 1.45; 95% CI, 0.91 to 2.32). Frequent paracetamol intake in the last year increased the risk of wheezing (OR, 3.3; 95% CI, 1.54 to 7.18), rhinitis (OR, 1.61; 95% CI, 1.33 to 1.95), or eczema (OR, 1.82; 95% CI, 1.24 to 2.66).
Frequent paracetamol exposure was associated with a significantly increased risk of wheezing and rhinitis and probably eczema in a Mexican population of children.
有证据表明，成人和儿童使用对乙酰氨基酚与特应性之间存在某种联系。
我们旨在调查在墨西哥儿童群体中，是否能找到更多关于对乙酰氨基酚摄入量与过敏之间存在联系的流行病学依据。
在一项横断面研究设计中，我们对3493名6至7岁的儿童应用了国际儿童哮喘及过敏研究（ISAAC）问卷。进行了两项分析：（1）若儿童从新生儿期到6至7岁期间曾出现过喘息、鼻炎或湿疹，则被归类为病例组；若从未经历过这些情况，则被归类为对照组。（2）若儿童在研究前12个月内出现过喘息、鼻炎或湿疹，则被归类为病例组。若对乙酰氨基酚在生命的第一年（第一项分析）或过去12个月（第二项分析）中频繁摄入，则视为阳性。
生命第一年摄入对乙酰氨基酚与喘息风险增加显著相关（调整后的优势比[OR]为1.69；95%置信区间[CI]为1.23至2.34）以及鼻炎（调整后的OR为1.37；95%CI为1.20至1.59），但与湿疹无关（调整后的OR为1.45；95%CI为0.91至2.32）。过去一年频繁摄入对乙酰氨基酚会增加喘息（OR为3.3；95%CI为1.54至7.18）、鼻炎（OR为1.61；95%CI为1.33至1.95）或湿疹（OR为1.82；95%CI为1.24至2.66）的风险。
在墨西哥儿童群体中，频繁接触对乙酰氨基酚与喘息、鼻炎风险显著增加以及可能的湿疹有关。
