Madhusoodanan Subramoniam, Moise Despina
Department of Psychiatry, State University of New York, Health Science Center at Brooklyn and St. John's Episcopal Hospital, Far Rockaway, NY 11691, USA.
J Clin Psychiatry. 2006 Jul;67(7):1110-3. doi: 10.4088/jcp.v67n0714.
To study the effect of risperidone on prolactin levels in 3 adolescent patients.
This is a case study of 3 adolescent patients with DSM-IV diagnosis of schizophreni-form disorder, major depressive disorder with psychotic features, or chronic undifferentiated schizophrenia who were treated in inpatient and outpatient psychiatric settings with risperidone. Patients developed hyperprolactinemia with clinical symptoms. Risperidone was discontinued gradually over 2 weeks, and patients were treated with other atypical antipsychotics.
Prolactin levels returned to normal, and clinical symptoms of hyperprolactinemia resolved in all 3 patients after 2 weeks of tapering and discontinuation of risperidone.
Hyperprolactinemia can be a troublesome side effect with potentially serious complications. It is being increasingly reported in younger patients treated with risperidone. Recognition and treatment of this condition including switching to a prolactin-sparing agent are important to prevent this complication.
研究利培酮对3例青少年患者催乳素水平的影响。
这是一项针对3例青少年患者的病例研究，这些患者被诊断为DSM-IV精神分裂症样障碍、伴有精神病性特征的重度抑郁症或慢性未分化型精神分裂症，在住院和门诊精神科环境中接受利培酮治疗。患者出现高催乳素血症并伴有临床症状。利培酮在2周内逐渐停用，患者接受其他非典型抗精神病药物治疗。
在利培酮逐渐减量并停用2周后，所有3例患者的催乳素水平恢复正常，高催乳素血症的临床症状得到缓解。
高催乳素血症可能是一种麻烦的副作用，伴有潜在的严重并发症。越来越多的报道称，使用利培酮治疗的年轻患者出现了这种情况。认识并治疗这种疾病，包括改用不引起催乳素升高的药物，对于预防这种并发症很重要。
