Parkes D G, Coghlan J P, McDougall J G, Scoggins B A
Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Australia.
J Cardiovasc Pharmacol. 1990 Jan;15(1):16-21. doi: 10.1097/00005344-199001000-00003.
The effects of pretreatment with atrial natriuretic factor (ANF) on the pressor responsiveness to injections of angiotensin II (ANGII), arginine vasopressin (AVP), and norepinephrine (NE), as well as the effect of pretreatment with ANGII on the hypotensive responses to ANF injection were studied in conscious sheep. The hemodynamic effects of ANF infusion (100 micrograms/h for 60 min) were also examined in animals pretreated with the angiotensin-converting enzyme (ACE) inhibitor, captopril. Infusion of ANF attenuated the pressor responsiveness to exogenous AII and NE, but caused no significant change in the blood pressure increases produced by vasopressin. In contrast, infusion of AII had no effect on the immediate hypotensive response to ANF injection. Infusion of ANF for 60 min produced similar hemodynamic actions in sheep during ACE inhibition as compared with the responses observed in normal sheep, although the reduction in cardiac output and increase in calculated total peripheral resistance was attenuated. Infusion of captopril increased plasma concentration of renin (PRC), and infusion of ANF produced no further change in PRC. In conclusion, the short-term cardiovascular responses to ANF infusion in conscious sheep are not mediated solely by inhibition of the renin-angiotensin system. However, ANF attenuates the pressor actions of pharmacologic doses of exogenous ANGII and NE. In contrast, the vasodepressor response to exogenous ANF injection was not altered in animals receiving ANGII infusion. This study suggests that ANF may be important in regulating the effects of endogenous vasoconstrictor hormones on blood pressure (BP).
在清醒绵羊中研究了心房利钠因子（ANF）预处理对注射血管紧张素II（ANGII）、精氨酸加压素（AVP）和去甲肾上腺素（NE）的升压反应性的影响，以及ANGII预处理对ANF注射的降压反应的影响。还在接受血管紧张素转换酶（ACE）抑制剂卡托普利预处理的动物中检查了ANF输注（100微克/小时，持续60分钟）的血流动力学效应。输注ANF减弱了对外源性AII和NE的升压反应性，但对血管加压素引起的血压升高没有显著影响。相反，输注AII对ANF注射的即时降压反应没有影响。与正常绵羊的反应相比，在ACE抑制期间，输注ANF 60分钟在绵羊中产生了类似的血流动力学作用，尽管心输出量的降低和计算得出的总外周阻力的增加有所减弱。输注卡托普利增加了血浆肾素浓度（PRC），输注ANF后PRC没有进一步变化。总之，清醒绵羊中对ANF输注的短期心血管反应并非仅由肾素-血管紧张素系统的抑制介导。然而，ANF减弱了药理剂量的外源性ANGII和NE的升压作用。相反，接受ANGII输注的动物对外源性ANF注射的血管舒张降压反应没有改变。这项研究表明，ANF在调节内源性血管收缩激素对血压（BP）的影响方面可能很重要。
