Rando Oliver J, Paulsson Johan
Bauer Center for Genomics Research, Harvard University, 7 Divinity Avenue, Cambridge, Massachusetts 02138.
Dev Cell. 2006 Aug;11(2):134-6. doi: 10.1016/j.devcel.2006.07.012.
Chromatin-based repression is a major mechanism for epigenetically heritable variation. Work in the July 21 issue of Molecular Cell quantitatively examines transcriptional silencing in individual yeast cells, demonstrating locus-specific effects and finding that different silencing mutants exhibit qualitatively distinct single-cell defects.
基于染色质的基因沉默是表观遗传可遗传变异的主要机制。发表于7月21日《分子细胞》杂志上的一项研究定量检测了单个酵母细胞中的转录沉默，揭示了基因座特异性效应，并发现不同的沉默突变体表现出性质截然不同的单细胞缺陷。
