额颞叶痴呆中调控异常的蛋白质
Aberrantly regulated proteins in frontotemporal dementia.
作者信息
Schweitzer Kelly, Decker Emily, Zhu Liping, Miller Richard E, Mirra Suzanne S, Spina Salvatore, Ghetti Bernardino, Wang Mu, Murrell Jill
机构信息
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
出版信息
Biochem Biophys Res Commun. 2006 Sep 22;348(2):465-72. doi: 10.1016/j.bbrc.2006.07.113. Epub 2006 Jul 28.
Non-Alzheimer's disease of the frontal type, or frontotemporal dementia (FTD), is the second most common form of dementia. Yet, a detailed characterization of the disease has been especially limiting. To identify mechanisms possibly involved in disease pathology or progression, a proteomic analysis of proteins isolated from human frontal cortex with frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) was performed. We used 2D gel electrophoresis and MALDI-TOF to identify a total of 24 proteins differentially expressed in FTDP-17. We identified a ubiquitin C-terminal hydrolase, UCHL1, as well as several proteins involved in oxidative stress to be differentially expressed. Data presented implicate UCHL1 and ubiquitin-mediated degradation as well as oxidative stress response in disease pathology or progression.
额颞叶型非阿尔茨海默病，即额颞叶痴呆（FTD），是第二常见的痴呆形式。然而，对该疾病的详细特征描述一直特别有限。为了确定可能参与疾病病理或进展的机制，我们对从患有与17号染色体相关的额颞叶痴呆和帕金森综合征（FTDP - 17）的人类额叶皮质中分离出的蛋白质进行了蛋白质组学分析。我们使用二维凝胶电泳和基质辅助激光解吸电离飞行时间质谱（MALDI - TOF）共鉴定出24种在FTDP - 17中差异表达的蛋白质。我们鉴定出一种泛素C末端水解酶UCHL1以及几种参与氧化应激的蛋白质存在差异表达。所呈现的数据表明UCHL1、泛素介导的降解以及氧化应激反应与疾病病理或进展有关。
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