Harrison Susan M W, Harrison Douglas A
Department of Biology, University of Kentucky, 101 T.H. Morgan Building, Lexington, KY 40506, USA.
Semin Cell Dev Biol. 2006 Aug;17(4):518-33. doi: 10.1016/j.semcdb.2006.07.004. Epub 2006 Jul 13.
Stem cells are self-renewing multipotent cells essential for development or homeostasis of many tissues. Stem cell populations can be found in most multicellular plants and animals. The mechanisms by which these populations are maintained are diverse, utilizing both intrinsic and extrinsic factors to regulate cell division and differentiation. The genetic tools of the fruitfly, Drosophila melanogaster, have permitted detailed characterization of two stem cell populations. In this review, we will examine these contrasting stem cell model systems from Drosophila and their relevance to stem cell populations in other organisms.
