Lim Vanessa K, Polych Melody A, Holländer Antje, Byblow Winston D, Kirk Ian J, Hamm Jeff P
Department of Psychology, Research Centre for Cognitive Neuroscience, The University of Auckland, Private Bag 92019, Auckland, New Zealand.
Clin Neurophysiol. 2006 Oct;117(10):2308-14. doi: 10.1016/j.clinph.2006.06.713. Epub 2006 Aug 4.
This study investigated whether kinesthetic and/or visual imagery could alter the contingent negative variation (CNV) for patients with Parkinson's disease (PD).
The CNV was recorded in six patients with PD and seven controls before and after a 10min block of imagery. There were two types of imagery employed: kinesthetic and visual, which were evaluated on separate days.
The global field power (GFP) of the late CNV did not change after the visual imagery for either group, nor was there a significant difference between the groups. In contrast, kinesthetic imagery resulted in significant group differences pre-, versus post-imagery GFPs, which was not present prior to performing the kinesthetic imagery task. In patients with PD, the CNV amplitudes post-, relative to pre-kinesthetic imagery, increased over the dorsolateral prefrontal regions and decreased in the ipsilateral parietal regions. There were no such changes in controls.
A 10-min session of kinesthetic imagery enhanced the GFP amplitude of the late CNV for patients but not for controls.
While the study needs to be replicated with a greater number of participants, the results suggest that kinesthetic imagery may be a promising tool for investigations into motor changes, and may potentially be employed therapeutically, in patients with Parkinson's disease.
本研究调查了动觉和/或视觉意象是否会改变帕金森病（PD）患者的关联性负变（CNV）。
在10分钟的意象训练前后，记录6例PD患者和7例对照者的CNV。采用两种意象类型：动觉和视觉，在不同日期进行评估。
两组在视觉意象训练后，晚期CNV的全域场功率（GFP）均未改变，两组之间也无显著差异。相比之下，动觉意象训练导致意象训练前后GFP出现显著的组间差异，而在进行动觉意象任务之前并未出现这种差异。在PD患者中，相对于动觉意象训练前，动觉意象训练后CNV振幅在背外侧前额叶区域增加，在同侧顶叶区域减少。对照组未出现此类变化。
10分钟的动觉意象训练增强了患者而非对照者晚期CNV的GFP振幅。
虽然该研究需要更多参与者进行重复验证，但结果表明动觉意象可能是研究运动变化的一种有前景的工具，并且可能在帕金森病患者的治疗中得到应用。
