贵金属经济

Precious metal economy.

作者信息

Merchant Sabeeha S, Sagasti Alvaro

机构信息

Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, California 90095, USA.

出版信息

Cell Metab. 2006 Aug;4(2):99-101. doi: 10.1016/j.cmet.2006.07.003.

DOI:10.1016/j.cmet.2006.07.003

PMID:16890535

Abstract

The zebrafish is emerging as a system of choice for modeling human disease. In this issue of Cell Metabolism, Mendelsohn et al. (2006) describe a model for Menkes disease, a genetic disorder in copper utilization. Using genetic and chemical screens, the authors highlight the impact of maternal nutrition on embryo development. The work reveals a hierarchy of temporal and dosage-dependent phenotypes for copper nutrition.

摘要

斑马鱼正逐渐成为用于模拟人类疾病的首选系统。在本期《细胞代谢》中，门德尔松等人（2006年）描述了一种针对门克斯病（一种铜利用方面的遗传疾病）的模型。通过遗传和化学筛选，作者强调了母体营养对胚胎发育的影响。这项研究揭示了铜营养在时间和剂量依赖性表型上的层级关系。