Whittaker James W
Department of Science and Engineering, School of Medicine, Oregon Health and Science University, Beaverton, OR 97006-8921, USA.
Biochim Biophys Acta. 2010 Feb;1804(2):298-307. doi: 10.1016/j.bbapap.2009.08.014. Epub 2009 Aug 20.
Manganese superoxide dismutase is an important antioxidant defense metalloenzyme that protects cells from damage by the toxic oxygen metabolite, superoxide free radical, formed as an unavoidable by-product of aerobic metabolism. Many years of research have gone into understanding how the metal cofactor interacts with small molecules in its catalytic role. In contrast, very little is presently known about how the protein acquires its metal cofactor, an important step in the maturation of the protein and one that is absolutely required for its biological function. Recent work is beginning to provide insight into the mechanisms of metal delivery to manganese superoxide dismutase in vivo and in vitro.
锰超氧化物歧化酶是一种重要的抗氧化防御金属酶，可保护细胞免受有毒氧代谢产物超氧自由基的损伤，超氧自由基是有氧代谢不可避免的副产物。多年来，人们一直在研究金属辅因子在其催化作用中如何与小分子相互作用。相比之下，目前对于该蛋白质如何获得其金属辅因子知之甚少，这是蛋白质成熟过程中的一个重要步骤，也是其生物学功能所绝对必需的。最近的研究开始为体内和体外向锰超氧化物歧化酶输送金属的机制提供见解。
