Xu Bing-Liang, Tao Yi
College of Grassland Sciences, Gansu Agriculture University, Lanzhou, PR China.
J Theor Biol. 2006 Nov 21;243(2):214-21. doi: 10.1016/j.jtbi.2006.06.003. Epub 2006 Jun 12.
The steady-state statistics of a single gene auto-regulatory genetic network with the additive external Gaussian white noises is investigated. The main result shows that the negative feedback will result in that the mRNA noise has a positive contribution to the protein noise, but the positive feedback will result in that the mRNA noise has a negative contribution to the protein noise. If there is no feed back, then the contribution of mRNA noise to protein noise is always positive. On the other hand, the analysis and numerical simulations of linear and nonlinear feedback show that it is possible that the negative feedback increases, but the positive feedback decreases, the protein noise.
研究了具有加性外部高斯白噪声的单基因自调控遗传网络的稳态统计特性。主要结果表明，负反馈会导致mRNA噪声对蛋白质噪声有正向贡献，而正反馈会导致mRNA噪声对蛋白质噪声有负向贡献。如果没有反馈，那么mRNA噪声对蛋白质噪声的贡献始终为正。另一方面，线性和非线性反馈的分析与数值模拟表明，负反馈可能增加蛋白质噪声，而正反馈可能降低蛋白质噪声。
