[标准风险急性淋巴细胞白血病患儿高剂量甲氨蝶呤（3 g/m²）的清除率及耐受性评估]
[Assessment of elimination and tolerance of high dose of methotrexate (3 g/m2) in children with standard-risk acute lymphoblastic leukemia].
作者信息
Cwliklińska Magdalena, Balwierz Walentyna, Nowak Jacek, Stanuch Helena
机构信息
Klinika Onkologii i Hematologii Dzieciecej P-A Instytutu Pediatrii Collegium Medicum Uniwersytetu Jagiellońskiego w Krakowie.
出版信息
Przegl Lek. 2006;63(1):15-20.
We assessed correlation between the elimination of methotrexate administered in dose 3 g/m2 during consolidation phase and the early complications in 129 children treated for acute lymphoblastic leukemia. Among 500 chemotherapy cycles included in the analysis the elimination of methotrexate was delayed in 66 (13.2%) cycles in 43 (33.3%) of patients. Influence of methotrexate on selected liver and renal function tests was analyzed. We made an attempt of early identification of patients with high risk for delayed methotrexate elimination and subsequent toxicities.
我们评估了129例接受急性淋巴细胞白血病治疗的儿童在巩固期给予3 g/m²剂量甲氨蝶呤后的清除情况与早期并发症之间的相关性。在纳入分析的500个化疗周期中，43例（33.3%）患者的66个周期（13.2%）中甲氨蝶呤清除延迟。分析了甲氨蝶呤对选定的肝功能和肾功能检查的影响。我们尝试早期识别甲氨蝶呤清除延迟及后续毒性高危患者。
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