Morse Linda, Calarese Pamela
Dana-Farber Cancer Institute, Boston, MA. 02115, USA.
Semin Oncol Nurs. 2006 Aug;22(3):152-62. doi: 10.1016/j.soncn.2006.04.005.
To discuss the mechanism by which epidermal growth factor receptor (EGFR)-targeted agents work, the resulting cutaneous toxicities, the pathophysiology of the unique rash associated with these agents, and the management of these skin problems.
Published scientific papers, review articles, book chapters, and clinical experiences.
These new targeted agents result in unique cutaneous toxicities. Researchers and clinicians have made numerous suggestions for managing the various side effects, although there is currently no research to guide evidence-based practice.
With any new treatment option, it is imperative that nurses understand how agents work to enrich their own knowledge base, as well as have a strong foundation for patient education. It is important that nurses understand potential side effects of these agents, know of possible interventions, and participate in research to identify effective interventions.
探讨表皮生长因子受体（EGFR）靶向药物的作用机制、由此产生的皮肤毒性、与这些药物相关的独特皮疹的病理生理学以及这些皮肤问题的管理。
已发表的科学论文、综述文章、书籍章节及临床经验。
这些新型靶向药物会导致独特的皮肤毒性。尽管目前尚无指导循证实践的研究，但研究人员和临床医生已针对管理各种副作用提出了众多建议。
对于任何新的治疗选择，护士必须了解药物的作用方式以丰富自身知识库，并为患者教育奠定坚实基础。护士了解这些药物的潜在副作用、知晓可能的干预措施并参与研究以确定有效干预措施非常重要。
