Lack of association of VEGF promoter polymorphisms with sporadic ALS.
作者信息
Chen W, Saeed M, Mao H, Siddique N, Dellefave L, Hung W-Y, Deng H-X, Sufit R L, Heller S L, Haines J L, Pericak-Vance M, Siddique T
机构信息
Davee Department of Neurology and Clinical Neurosciences, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
出版信息
Neurology. 2006 Aug 8;67(3):508-10. doi: 10.1212/01.wnl.0000227926.42370.04.
The authors tested the association of three vascular endothelial growth factor (VEGF) promoter polymorphisms with sporadic ALS (SALS) to verify the results of a previous study and to investigate their modifier effects on the subphenotypes of SALS in a large family-based and case-control cohort of North American white subjects (N = 1,603). They did not find any association of the VEGF promoter polymorphisms with SALS or its subphenotypes, suggesting that they do not have a direct causal role in ALS.
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