Jessen F, Traeber F, Freymann K, Maier W, Schild H H, Block W
Department of Psychiatry, University of Bonn, Germany.
Neurology. 2006 Aug 8;67(3):528-30. doi: 10.1212/01.wnl.0000228218.68451.31.
In this proton magnetic resonance spectroscopy ((1)H-MRS) study, the authors correlated cognitive improvement after 3 months of treatment with donepezil with changes of N-acetylaspartate (NAA) level and NAA/Creatine (Cr) ratio in the medial temporal and parietal lobe of 17 patients with Alzheimer disease. Treatment response was associated with an increase of NAA and NAA/Cr in the parietal lobe. Low baseline NAA/Cr in the parietal lobe predicted positive treatment outcome.
在这项质子磁共振波谱（(1)H-MRS）研究中，作者将17例阿尔茨海默病患者接受多奈哌齐治疗3个月后的认知改善与内侧颞叶和顶叶中N-乙酰天门冬氨酸（NAA）水平及NAA/肌酸（Cr）比值的变化进行了关联分析。治疗反应与顶叶中NAA及NAA/Cr的增加相关。顶叶较低的基线NAA/Cr可预测积极的治疗结果。
