Singh Baljinder, Manoj Rohit, Vikas Prasad, Bhattacharya Anish, Sharma Yashpaul, Mittal Bhagwant Rai
Department of Nuclear Medicine, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh-160012, India.
Hell J Nucl Med. 2006 May-Aug;9(2):94-8.
The aim of the present study was to evaluate the correlation amongst left ventricular (LV) functional parameters estimated by gated single photon emission tomography (GSPET) and two-dimensional (2D) M-mode, echocardiography (ECHOC). GSPET was performed in a single day stress/rest protocol by using either technetium-99m methoxy-isobutyl-isonitrile ((99m)Tc-MIBI) or technetium-99m tetrofosmin ((99m)Tc-myoview) in 36 consecutive patients, 21 males and 15 females; mean age 57.6+/-11.8 y, range 32-82 y. The various LV parameters studied were: ejection fraction (EF), end systolic volume (ESV), end diastolic volume (EDV), stroke volume (SV) and LV mass (LVM). The GSPET data were reconstructed using an automatic algorithm employing filtered back projection (FBP) and further analyzed by Emory cardiac (EC) toolbox versions EO-00369 and EO-00733 for the quantitative determinations of these parameters. All patients underwent ECHOC within 1-2 h of the post-stress data acquisition of GSPET. Our results showed that the LV volumes and the LVM showed good correlation (r=0.749 to 0.952, P=0.01). These values could thus be used interchangeably. The assessment of these parameters by GSPET therefore does not seem to be affected by the dose of the radioactivity administered as the dose of the (99m)Tc-labeled myocardial agents for acquiring rest study was approximately four times higher than that for the stress study. Our results also showed that the mean +/- SD values of the volumes and the EF of the LV evaluated by the two techniques, differed significantly except significant correlations for ESV, EDV and LVEF were observed between the two methods: r=0.574 to 0.954; 0.347 to 0.952 and 0.516 to 0.876 respectively. On the other hand, a wide disagreement was observed in estimating the LVM by the two techniques. The LVM measurements by 2D ECHOC were approximately double the values estimated by GSPET. Despite the large disagreement, a small correlation (r=0.33, P=0.05) was observed for LVM between the two techniques. In conclusion, although we observed a good correlation for LV volumes and LVM between the GSPET and the ECHOC techniques, yet these two techniques cannot be used interchangeably.
本研究的目的是评估门控单光子发射断层扫描（GSPET）和二维（2D）M型超声心动图（ECHOC）所估计的左心室（LV）功能参数之间的相关性。对36例连续患者（21例男性和15例女性，平均年龄57.6±11.8岁，范围32 - 82岁）采用一日应激/静息方案进行GSPET检查，使用锝-99m甲氧基异丁基异腈（（99m）Tc-MIBI）或锝-99m替曲膦（（99m）Tc-myoview）。所研究的各种LV参数包括：射血分数（EF）、收缩末期容积（ESV）、舒张末期容积（EDV）、每搏输出量（SV）和左心室质量（LVM）。GSPET数据使用采用滤波反投影（FBP）的自动算法进行重建，并通过Emory心脏（EC）工具箱版本EO - 00369和EO - 00733进一步分析以定量测定这些参数。所有患者在GSPET应激后数据采集的1 - 2小时内接受ECHOC检查。我们的结果表明，LV容积和LVM显示出良好的相关性（r = 0.749至0.952，P = 0.01）。因此这些值可以互换使用。因此，GSPET对这些参数的评估似乎不受所给予放射性剂量的影响，因为用于获取静息研究的（99m）Tc标记心肌剂的剂量大约是应激研究剂量的四倍。我们的结果还表明，两种技术评估的LV容积和EF的平均值±标准差显著不同，除了ESV、EDV和LVEF在两种方法之间观察到显著相关性：分别为r = 0.574至0.954；0.347至0.952和0.516至0.876。另一方面，两种技术在估计LVM方面存在很大差异。二维ECHOC测量的LVM值大约是GSPET估计值的两倍。尽管存在很大差异，但两种技术之间的LVM仍观察到小的相关性（r = 0.33，P = 0.05）。总之，虽然我们观察到GSPET和ECHOC技术之间LV容积和LVM有良好的相关性，但这两种技术不能互换使用。
