中年大鼠脑区单胺水平及利用情况

Regional brain monoamine levels and utilization in middle-aged rats.

作者信息

Hadfield M G, Milio C

机构信息

Department of Pathology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298.

出版信息

Life Sci. 1990;46(4):295-9. doi: 10.1016/0024-3205(90)90036-q.

DOI:10.1016/0024-3205(90)90036-q

PMID:1689446

Abstract

Significant changes in monoamine levels and utilization were noted in certain brain regions of middle-aged Fisher 344 rats when compared with young adult controls. In the prefrontal cortex and septum, 3,4 dihydroxyphenylglycol (MHPG) and the MHPG/norepinephrine (NE) ratio were decreased. The septum also showed increases in dopamine (DA) and dihydroxyphenylacetic acid (DOPAC) but there was a decrease in the DOPAC/DA ratio. The striatum showed an increase in the MPHG/NE ratio and an increase in DOPAC. The hippocampus and thalamus showed an increase in 5-hydroxyindoleacetic acid (5HIAA). This demonstrates that selected neurotransmitter systems in the brain are altered at an early stage of senescence. This could lead to ensuing neurological deficits.

摘要

与年轻成年对照大鼠相比，中年Fisher 344大鼠的某些脑区单胺水平和利用率出现显著变化。在额叶前皮质和隔区，3,4-二羟基苯乙二醇（MHPG）以及MHPG/去甲肾上腺素（NE）比值降低。隔区还显示多巴胺（DA）和二羟基苯乙酸（DOPAC）增加，但DOPAC/DA比值降低。纹状体显示MPHG/NE比值增加以及DOPAC增加。海马体和丘脑显示5-羟吲哚乙酸（5HIAA）增加。这表明大脑中特定的神经递质系统在衰老早期就发生了改变。这可能会导致随后出现神经功能缺损。